Endocrinology

About our Endocrinology service

Our Paediatric Endocrinology Team delivers expert, compassionate care for children and young people with a wide range of hormone-related conditions.

We specialise in the diagnosis and management of disorders affecting growth, puberty, thyroid function, and pituitary dysfunction. Our service also includes dedicated pathways for pituitary tumours, paediatric and adolescent gynaecology (PAG), adrenal conditions, endocrine cancer, late endocrine effects of cancer treatment, and differences of sex development (DSD).

How do we provide care?

We provide comprehensive, family-centred care from your initial assessment through to long-term follow-up care and transition into adult services. Our multidisciplinary approach ensures that every child benefits from coordinated care across medical, nursing, psychology, and allied health teams. We also work closely with surgical colleagues in our pituitary tumour, DSD, thyroid, and PAG clinics.

We work alongside other teams who look after children with metabolic bone diseases, complications of excess weight (CEW), and diabetes.

Whether managing common endocrine issues or supporting families through rare and complex diagnoses, our team is committed to delivering personalised care that empowers children and their families at every stage of their journey.

Some of the conditions managed by the Paediatric Endocrinology Team include:

• Adrenal gland disorders (Adrenal insufficiency, CAH, Addison’s disease, steroid induced adrenal insufficiency, and Cushing’s Syndrome)
• Congenital hyperinsulinism (CHI)
• Disorders of growth (tall and short stature)
• Disorders of puberty (early and delayed puberty)
• Differences of sex development (DSD)
• Endocrine disorders of sodium regulation e.g. AVP deficiency and pseudohypoaldosteronism
• Endocrine late effects related to Neurosurgical/Oncology/Haematology conditions
• Growth hormone deficiency and other conditions requiring growth hormone
• Hypopituitarism, and septo-optic dysplasia
• Klinefelter Syndrome
• Multiple Endocrine Neoplasia and other endocrine cancer syndromes
• Neonatal endocrinology
• Noonan Syndrome
• Paediatric and Adolescent Gynaecology (PAG)
• Prader Willi Syndrome
• Rare endocrine conditions and syndromes
• Thyroid disorders (underactive thyroid (hypothyroidism) and overactive thyroid  (hyperthyroidism))
• Turner Syndrome

Our research

Sheffield Children’s hosts a diverse and evolving paediatric endocrinology research portfolio spanning growth and puberty disorders, adrenal and pituitary disease, hypothalamic and pituitary tumours, and late endocrine effects in childhood cancer survivors. There is a strong focus on adrenal disorders, including the development of novel non-invasive diagnostics for adrenal function, characterisation of adrenal physiology in premature infants, and clinical research into adrenal insufficiency. A major research theme centres on inborn errors of adrenal steroidogenesis, particularly congenital adrenal hyperplasia (CAH), with work addressing optimisation of treatment and healthcare delivery, and the development of improved biomarkers and monitoring strategies to enhance long-term outcomes. Additional areas include differences of sex development, androgen excess, paediatric and adolescent gynaecology (PAG), thyroid disease, neonatal endocrinology alongside translational studies using novel models to understand systemic effects of disrupted hormone action.

The paediatric Endocrinology Department has strong collaborations with the University of Sheffield and Sheffield Hallam University and is leading on innovation in child health technology through initiatives such as the National Centre for Child Health Technology (NCCHT), supporting the development and evaluation of novel diagnostic and digital health solutions. The department is also an active participant in national and international multicentre clinical trials, contributing to the advancement of evidence-based care in paediatric endocrinology.

Collectively, these research areas reflect a comprehensive research approach aimed at improving diagnosis, management, and long-term outcomes in paediatric endocrine conditions.