Dr Charlotte Elder

Dr Charlotte Elder

Role: Consultant in Paediatric Endocrinology and Diabetes

Charlotte Elder received her undergraduate medical degree from Imperial College, (University of London) UK in 1999 and, after initially training as a general practitioner, retrained in paediatrics and further specialised in paediatric endocrinology and diabetes. She moved from London to Sheffield in 2005 in pursuit of excellent paediatric endocrinology training combined with affordable housing and fabulous local countryside.

In May 2018 Dr Elder took up the post of Consultant in Paediatric Endocrinology and Diabetes at Sheffield Children’s Hospital and three months later was appointed as Senior Clinical Lecturer at the University of Sheffield. Clinically her specialist interests are adrenal insufficiency and paediatric and adolescent gynaecology.

Research Interests

Charlotte Elder’s main research has been in the development of a non-invasive Short Synacthen Test for adrenal insufficiency, with a novel formulation of Synacthen for nasal administration and the measurement of the glucocorticoid response in saliva samples. She has led a team over five pharmacokinetic studies in adults and children. There is a patent application filed for the novel formulation and both commercial and research arms to the current workstream.

Current Projects

  • NeSST2 Study: Validation of non-invasive Short Synacthen Test with research and commercial workstreams. Principal investigator
  • “Hanging out your dirty washing” – male sexual health-seeking behaviour explored through exhibition. Lead investigator.
  • IRRATE: Inter and intra-Rater Reliability of the Accuracy Testicular volume Estimation. Study, in collaboration with design engineers from Sheffield Hallam University, to engineer dummies for simulated testicular volume estimation; examine accuracy of orchidometer assessment and the impact of training. Lead investigator.
  • 1 mcg dilution study: Lab based study examining the reliability of making up low-dose Synacthen. Supervising investigator.
  • International survey on tests of hypothalamic-pituitary-adrenal axis and use of the Short Synacthen test. Supervising investigator

Recent Publications

  • Elder CJ, Langley J, Stanton A, De Silva S, Akbarian-Tefaghi L, Wales JHK, Wright NP. A Simulation Study Assessing the Accuracy and Reliability of Orchidometer Estimation of Testicular Volume. Clin Endo (Oxf) 2019. (DOI 10.1111/cen.13923)
  • Elder CJ, Harrison RH, Cross AS, Vilela R, Keevil BG, Wright NP, Ross RJ. Use of salivary cortisol and cortisone in the high- and low-dose Synacthen test. Clin Endocrinol (Oxf) 2018,88:772-778 (DOI: 10.1111/cen.13509) (selected for monthly commentary)
  • Cross AS, Kemp EH, White A, Walker L, Meredith S, Sachdev P, Krone NP, Ross RJ, Wright NP, Elder CJ. International survey on high- and low-dose synacthen test and assessment of accuracy in preparing low-dose synacthen. Clin Endocrinol (Oxf) 2018;88:744-751 (selected as Editor’s choice)
  • Cockill TG, Hewitt A, Heafey C, Wright NP, Elder CJ. The use of a radiolucent template to improve bone age X-ray quality (BASIC study). J Ped Endocrinol Metab2017; 30(12): 1277-80
  • Elder CJ, Dimitri PJ. Diabetes Insipidus and the use of desmopressin in hospitalised children. Arch Dis Child Educ Pract Ed 2017; 102: 100-104
  • King DA, West NS, Elder CJ. Integrating teaching into everyday clinical practice. Arch Dis Child Educ Pract Ed 2017; 102: 94-99 (Commissioned, externally peer reviewed).
  • Elder CJ, Dimitri PJ. Hydrocortisone for adrenal insufficiency. Arch Dis Child Educ Pract Ed 2015;100 272-276
  • Elder CJ, Wright NP. Height estimation using long bone segment length is unlikely to play a role in the routine measurement of healthy pre-school children. Developmental Medicine and Child Neurology 2014. Invited commentary. Doi:10.1111dmcn.12536.
  • Elder CJ, Bishop NJ. Rickets Seminar. Lancet 2014; 383 (9929): 1665-1676
  • Elder CJ, Somerset LM, Ram V, Wright NP, Wales JK, Dimitri PJ. Letter in response to Chitale et al: Determining the utility of the 60-minute cortisol measurement in the Short Synacthen Test. Clin Endo 2014; 80 (6): 925
  • Jackson C, Wernham EM, Elder CJ, Wright NP. Early glycaemic control is predictive of long-term control: A retrospective observational study. Practical Diabetes2013; 30(1): 16-18
  • Elder CJ, Sachdev P, Wright NP. The Short Synacthen Test: A questionnaire survey of current usage. Archives of Diseases in Childhood 2012; 97: 870-873.

Sheffield Children’s NHS Foundation Trust
Sheffield Children's@SheffChildrens
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