Currently recruiting

Researchers at the University of Sheffield and Sheffield Children’s Hospital have developed a needle-free alternative. It uses a nasal spray instead of the injection and saliva rather than blood tests. As part of our development studies, funded by the Medical Research Council, we need to demonstrate that our new test using a nasal spray works as effectively as the Short Synacthen Test.

To do this we are asking volunteers to attend the hospital for four visits, at each visit they will either receive an active drug or a placebo through a nasal spray or by a needle.

We are looking to recruit healthy people aged between 4 and 69 years to attend the Clinical Research Facility at either Sheffield Children’s Hospital (children) or the Royal Hallamshire Hospital (adults) for four visits lasting approximately 3.5 hours at each visit. All reasonable expenses to attend each visit will be reimbursed.

If you are interested in finding out more about this study please contact our Research Team on r.innovation@nhs.net

The next stage is to test 200 healthy children in order to discover what constitutes a normal response to Nasacthin. This will enable us to set age and sex appropriate diagnostic cut-offs for what is an abnormal result.

We are looking to recruit healthy children aged between 0 to 18 years. On day 1 participants will collect 3 saliva samples across the day at home and on day 2 collect another saliva sample at home before coming to Sheffield Children’s for a Nasacthin Test – a saliva sample followed by a spray of our new medicine (Nasacthin) up each nostril, then a further saliva sample an hour later. The visit will last less than 2 hours.

We are compensating participants, parents and carers with £25 for the study visit to cover their expenses (transport, parking, lost income) and to suitably recognise their time and commitment.

If you are interested in finding out more about this study please contact the study team on scn-tr.nesst.2@nhs.net or 07584590503.

• Phone call (10 mins) – to arrange a visit the Royal Hallamshire Hospital
• Initial screening (30 mins) – to assess your child’s skin and answer any questions you may have
• Image collection (120 mins) – images of your child’s elbows and cheeks
• Sample collection (60 mins) – this involves a saliva sample, skin sample and a blood sample (which will be carried out at Sheffield Children’s)

For participating, all eligible young people will receive £75 in Amazon or Love2Shop vouchers. Taxis will be provided to and from the hospital as needed.

This study is organised by The University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust and is funded by Leo Pharma. This study has been reviewed and given a favourable opinion by the Yorkshire and the Humber Research Ethics Committee.

If the answer is yes, our local BADBIR team would like to hear from you!

For further information or to discuss your eligibility to participate, please ask your dermatologist or specialist nurse about BADBIR.

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