We are seeking recruits for the next research study in the development of our new non-invasive version of a diagnostic test for adrenal insufficiency. Adrenal insufficiency is a medical condition where the body’s adrenal glands do not produce enough of the important stress hormone cortisol. The current test, Short Synacthen Test, requires injection of the medicine (Synacthen) and blood tests. We have developed a new medicine, similar to Synacthen but that can be given up the nose via a nasal spray rather than into a vein. We then assess how the adrenal glands respond by measuring cortisol in samples of saliva rather than blood. This means no need for any blood tests or needles. Our new test is called the Nasacthin Test.
The next stage is to test 200 healthy children in order to discover what constitutes a normal response to Nasacthin. This will enable us to set age and sex appropriate diagnostic cut-offs for what is an abnormal result.
We are looking to recruit healthy children aged between 0 to 18 years. On day 1 participants will collect 3 saliva samples across the day at home and on day 2 collect another saliva sample at home before coming to Sheffield Children’s for a Nasacthin Test – a saliva sample followed by a spray of our new medicine (Nasacthin) up each nostril, then a further saliva sample an hour later. The visit will last less than 2 hours.
We are compensating participants, parents and carers with £25 for the study visit to cover their expenses (transport, parking, lost income) and to suitably recognise their time and commitment.
If you are interested in finding out more about this study please contact the study team on scn-tr.nesst.2@nhs.net or 07584590503.
