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Currently recruiting

research participant

Research at our hospital is all about getting a better understanding about medical conditions that affect the health of children and young people.

We use research to test new methods of treatment and to determine whether these new treatments are safe and how well they work.

Research can include testing new medicines or procedures, studying genetics, testing blood samples, taking measurements or completing questionnaires.



Research studies we are currently recruiting for are listed below.  If you have any questions, contact our Clinical Research Facility on 0114 271 7417 or email

Bone vibration study

We are looking for boys aged 7-13 to take part in a research study called ‘Vibration in boys who have a history of fracture’.

Find out more

Congenital Adrenal Hyperplasia (CAH)

Health status in Children and Young People with Congenital Adrenal Hyperplasia (CAH)

We are running a research project to look at the health of people with a condition called Congenital Adrenal Hyperplasia (CAH). We also want to develop novel tests that help these people to manage their condition better. We are looking to recruit healthy children and teenagers aged 8 to 18 years. As part of the study, we will collect a saliva and a blood sample.

We are paying parents/guardians of volunteers up to £40 in travel expenses and giving children a £20 high street voucher as a thank you.

If you are interested in finding out more about this study please contact Dr Nils Krone on 0114 2717508 or email

For further information you can also contact the national study coordinator Sundus Mahdi on 0114 3053875 or email

Encephalitis is inflammation of the brain caused by infection or when a person’s immune system goes wrong. Acquired brain injury, and in some cases death, are unfortunately outcomes of the condition.

As a result there are many reputable institutions dedicated to researching encephalitis and its consequences. The primary aims of such research are usually to minimise, and where possible, prevent deaths from the condition, as well as to reduce the unwanted outcomes resulting from the subsequent damage to the brain.

Research in recent years has led to the discovery of new causes; the invention of treatments that can reduce death and injury to the brain; diagnostic and management algorithms to aid diagnosing and treating clinicians; as well as improved understanding of the outcomes for patients and how best to manage them.

The Encephalitis Society supports research into encephalitis and often contributes to, and is involved in studies, led by leading academic and medical institutions. This means we can ensure the voices of those affected are represented before, during, and after a study takes place.

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Flu symptoms (ARCHIE)

The ARCHIE Study: The early use of Antibiotics for 'at Risk' CHildren with InfluEnza

Recruitment re-opens October 2017

If your child is aged 6 months to 12 years and has a long-term condition or was born prematurely, you and your child may be eligible to take part in the ARCHIE Study if your child gets a flu-like illness this winter.

Conditions include:

  • asthma
  • diabetes
  • cerebral palsy
  • immune system conditions
  • Down’s syndrome
  • heart, kidney or liver problems
  • premature baby

Find out more

Newborn screening

We are recruiting children and adult patients with one of several Newborn Screening (NBS) disorders.

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Osteogenesis Imperfecta (LINK)
The LINK Study is being conducted to evaluate the effect of an investigational medication on bone mineral density (BMD) and incidence of fractures in children 2 to 17 years of age with OI.

Who can take part

Children and adolescents may be eligible to participate in the LINK Study, provided the following criteria are met:

  • be between the ages of 2 and 17 (inclusive)
  • have been diagnosed with Osteogenesis Imperfecta Type I – IV
  • have a specific fracture history (to be discussed with/determined by your doctor)

There are other eligibility requirements to be reviewed with the study doctor. Only the study doctor can determine whether an individual is eligible for the study or not.

Taking part

The study staff will present a document that provides all the details about the study. This document is called an Informed Consent Form. People considering the study should make sure to read it carefully and ask questions about anything they do not understand. For example:

  • what procedures are involved in the study?
  • how long will the study take?
  • what happens if I want to stop participating?
  • what side effects are associated with the investigational product?
  • what other therapies are available to treat my medical condition?

Further information

For further details contact Kate Jones, Paediatric Research Officer on 0114 305 3171.

Pain medication (RELYON)
RELYON is a worldwide clinical research study enrolling children suffering from pain requiring prolonged release opioid treatment. We are investigating a strong pain medicine which is approved for the treatment of severe chronic pain in adults. The aim of the RELYON study is to find out if this pain medicine works in children too.

Find out more

Psoriasis (BADBIR)
Do you have Psoriasis? Are you taking tablets or using injections to treat your condition? Would you like to take part in a research study aiming to assess the safety and effectiveness of current psoriasis treatments?

If the answer is yes, our local BADBIR team would like to hear from you!

For further information or to discuss your eligibility to participate, please ask your dermatologist or specialist nurse about BADBIR.

Find out more

Type 1 Diabetes (TrialNet)
Type 1 diabetes is a life-long condition that occurs in both children and adults. It develops when the body attacks and destroys insulin producing cells in the pancreas.

TrialNet screens relatives of people with type 1 diabetes. They have a 15 times greater risk for developing the condition than people with no family history.

Who can take part

We can screen you for the Pathway to Prevention Study if you are:

  • 3 to 45 years old and have a brother, sister, child or parent with type 1 diabetes, OR
  • 3 to 20 years old and have a cousin, aunt, uncle, niece, nephew, half brother, half sister or grandparent with type 1 diabetes

The test

A small sample of blood is taken from your arm. The blood is tested for autoantibodies which are markers that show if the immune system is turned on.

You can have blood test at a TrialNet site or TrialNet can send you a test kit. You take the kit to your doctor or local lab to have your blood taken and then send it to TrialNet. We will have the results in 4-10 weeks.

Positive test

Testing positive means you are at greater risk than if you tested negative. We will ask you to join the monitoring part of the natural history study. You will come in once or twice for blood tests and we may invite you to join other studies testing ways to delay and prevent type 1 diabetes.

Find out more

For more information about TrialNet call Lynda Viles on 01143 053234 or visit the TrialNet website.

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November 2021: Our guidance for inpatients at Sheffield Children's has changed. Two named parents/carers may be permitted in inpatients only.See more about our guidance about inpatients