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Currently recruiting

research participant

Research at our hospital is all about getting a better understanding about medical conditions that affect the health of children and young people.

We use research to test new methods of treatment and to determine whether these new treatments are safe and how well they work.

Research can include testing new medicines or procedures, studying genetics, testing blood samples, taking measurements or completing questionnaires.

Studies we are currently recruiting for are listed below.  If you have any questions, contact our Clinical Research Facility on 0114 271 7417 or email

Adrenal insufficiency is the medical term for the body’s adrenal glands not producing enough of the vital stress hormone, cortisol. The current diagnostic test for adrenal insufficiency (Short Synacthen Test) is invasive, requiring hospital attendance, an intravenous injection and blood tests.

Researchers at the University of Sheffield and Sheffield Children’s Hospital have developed a needle-free alternative. It uses a nasal spray instead of the injection and saliva rather than blood tests. As part of our development studies, funded by the Medical Research Council, we need to demonstrate that our new test using a nasal spray works as effectively as the Short Synacthen Test.

To do this we are asking volunteers to attend the hospital for four visits, at each visit they will either receive an active drug or a placebo through a nasal spray or by a needle.

We are looking to recruit healthy people aged between 4 and 69 years to attend the Clinical Research Facility at either Sheffield Children’s Hospital (children) or the Royal Hallamshire Hospital (adults) for four visits lasting approximately 3.5 hours at each visit. All reasonable expenses to attend each visit will be reimbursed.

If you are interested in finding out more about this study please contact our Research Team on

NeSST2 Study
We are seeking recruits for the next research study in the development of our new non-invasive version of a diagnostic test for adrenal insufficiency. Adrenal insufficiency is a medical condition where the body’s adrenal glands do not produce enough of the important stress hormone cortisol. The current test, Short Synacthen Test, requires injection of the medicine (Synacthen) and blood tests. We have developed a new medicine, similar to Synacthen but that can be given up the nose via a nasal spray rather than into a vein. We then assess how the adrenal glands respond by measuring cortisol in samples of saliva rather than blood. This means no need for any blood tests or needles. Our new test is called the Nasacthin Test. 

The next stage is to test 200 healthy children in order to discover what constitutes a normal response to Nasacthin. This will enable us to set age and sex appropriate diagnostic cut-offs for what is an abnormal result.

We are looking to recruit healthy children aged between 0 to 18 years. On day 1 participants will collect 3 saliva samples across the day at home and on day 2 collect another saliva sample at home before coming to Sheffield Children’s for a Nasacthin Test – a saliva sample followed by a spray of our new medicine (Nasacthin) up each nostril, then a further saliva sample an hour later. The visit will last less than 2 hours.

We are compensating participants, parents and carers with £25 for the study visit to cover their expenses (transport, parking, lost income) and to suitably recognise their time and commitment.

If you are interested in finding out more about this study please contact the study team on or 07584590503.

SPOT (Skin Pathology assessment with Optical Technologies study - eczema research
The study is currently recruiting young volunteers with eczema to help develop new ways of looking at the skin using light based imaging.
When negatively affected by a skin condition such as eczema, the structure of our skin changes in many ways. New light-based imaging techniques have recently enabled us to see beneath the skin surface in a harmless way, giving us far more information than can be seen by eye. Our aim is to compare these new techniques against more traditional ones, with the goal of improving treatment and diagnosis of eczema in the future.

This study is looking for young people aged 11 to 16 with eczema on their elbows or on their face. The study is also recruiting adults with eczema on their elbows. It will involve:

  • Phone call (10 mins) – to arrange a visit the Royal Hallamshire Hospital
  • Initial screening (30 mins) – to assess your child’s skin and answer any questions you may have
  • Image collection (120 mins) – images of your child’s elbows and cheeks
  • Sample collection (60 mins) – this involves a saliva sample, skin sample and a blood sample (which will be carried out at Sheffield Children’s)

For participating, all eligible young people will receive £75 in Amazon or Love2Shop vouchers. Taxis will be provided to and from the hospital as needed.

This study is organised by The University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust and is funded by Leo Pharma. This study has been reviewed and given a favourable opinion by the Yorkshire and the Humber Research Ethics Committee.

If you would like to learn more about the SPOT study, email, call 0114 215 9539 or visit
Atopic Dermatitis (Eczema) - volunteers without atopic dermatitis needed
Are you interested in taking part in a research trial which could help improve the way we are able to care for patients with eczema?
The Pelistad Study is looking into the effects of atopic dermatitis – more commonly known as eczema – on children aged 6 to 11 years old both with and without the condition. During the study, children with atopic dermatitis will receive the study medicine and researchers will compare the skin of a child with atopic dermatitis who is taking the medicine to the skin of a child without atopic dermatitis.
The study – run by Sanofi – is currently recruiting children without atopic dermatitis, any skin conditions, or any other chronic medical conditions. Volunteers must be aged between 6 and 11 years old and there is reimbursement available for:
  • Reasonable travel expenses
  • Inconvenience fee for parent/carer (£12/hour)
  • Book token for participant (£30 – as approved by the Ethics Committee for study)
If you would like to learn more about the Pelistad Study, call 0114 305 3136 or email
Psoriasis (BADBIR)
Do you have Psoriasis? Are you taking tablets or using injections to treat your condition? Would you like to take part in a research study aiming to assess the safety and effectiveness of current psoriasis treatments?

If the answer is yes, our local BADBIR team would like to hear from you!

For further information or to discuss your eligibility to participate, please ask your dermatologist or specialist nurse about BADBIR.

Find out more

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