Skip to main content

Introducing “NeSST2” – the new ‘sniff’ and ‘spit’ test that measures the stress chemicals in your body

Person smiling, standing in a hospital corridor
20 May 2023

We’ve created a new test to measure the stress chemicals in your body!

There are some pretty cool things happening at our Clinical Research Facility at Sheffield Children’s and this is one of them!

Introducing “NeSST2” – some children, including a number on steroid medications are unable to produce a safe amount of the stress hormone, cortisol. This is called adrenal insufficiency which means they are less able to stay healthy in stressful situations such as when ill or having an operation. We want to understand the body’s ability to respond to stress and what the cut off for an abnormal response is.

The current test used to diagnose adrenal insufficiency requires children to visit the hospital for needles and blood tests but no more!

We’ve developed a new test which doesn’t involve needles or blood tests! Say hello to the new ‘sniff’ and ‘spit’ test, expect nasal sprays and saliva samples. Taking part will involve collecting four salivary samples at home and one visit to the Clinical Research Facility here at Sheffield Children’s which should take less than 2 hours.

We’re looking for 200, healthy, 0-16 year olds to get involved (we hope to be involving 17 and 18 year olds soon), could that be you?

To find out more or to take part in the NeSST2 study please call us on 07584590503 or email

You might also be interested in...

    [0] => Array
            [message] => You currently have access to a subset of Twitter API v2 endpoints and limited v1.1 endpoints (e.g. media post, oauth) only. If you need access to this endpoint, you may need a different access level. You can learn more here:
            [code] => 453


By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.